- 2-amino-4-methoxytoluene
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- $5.00 / 25kg
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2024-04-29
- CAS:50868-72-9
- Min. Order: 1kg
- Purity: 99.92%
- Supply Ability: 50000tons
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| | 5-Methoxy-2-methylaniline Basic information |
| | 5-Methoxy-2-methylaniline Chemical Properties |
| Melting point | 43-46 °C (lit.) | | Boiling point | 253°C(lit.) | | density | 1.0630 (rough estimate) | | refractive index | 1.5647 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Powder | | pka | 4.03±0.10(Predicted) | | color | Off-white to pale grey to yellow | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C8H11NO/c1-6-3-4-7(10-2)5-8(6)9/h3-5H,9H2,1-2H3 | | InChIKey | RPJXLEZOFUNGNZ-UHFFFAOYSA-N | | SMILES | C1(N)=CC(OC)=CC=C1C |
| | 5-Methoxy-2-methylaniline Usage And Synthesis |
| Chemical Properties | White to gray to tan crystalline powder | | Uses | 5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide. | | Uses | 5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide. | | Synthesis | Under nitrogen atmosphere, 4-methoxy-1-methyl-3-nitrobenzene (18.0 g, 108 mmol) was dissolved in 160 mL of 1,2-dimethoxyethane (DME), followed by the addition of 10% Pd/C catalyst (0.9 g). Hydrazine hydrate (16.17 g, 323 mmol) was slowly added dropwise to the above solution. The reaction mixture was heated to reflux and stirred continuously for 4 hours. After that, 3 mL of hydrazine hydrate was added additionally and stirring was continued under reflux conditions for 2 days. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product 5-methoxy-2-methylaniline as a yellow oil. After further vacuum drying, the product solidified to a pale yellow solid in a yield of 14.8 g (100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.94 (d, J = 7.53 Hz, 1H), 6.28 (d, J = 7.53 Hz, 1H), 6.26 (s, 1H), 3.78 (s, 3H), 3.5 (br, 1H), 2.10 (s, 3H), 1.6 (br, 1H). | | References | [1] Patent: WO2009/117097, 2009, A1. Location in patent: Page/Page column 70-71
[2] Tetrahedron, 2018, vol. 74, # 12, p. 1294 - 1306
[3] Justus Liebigs Annalen der Chemie, 1882, vol. 215, p. 83
[4] Journal of the Chemical Society, 1929, p. 870
[5] Journal of the Chemical Society, 1925, vol. 127, p. 995 |
| | 5-Methoxy-2-methylaniline Preparation Products And Raw materials |
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