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1,3-Diaza-spiro[4.4]nonane-2,4-dione

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1,3-Diaza-spiro[4.4]nonane-2,4-dione manufacturers
1,3-Diaza-spiro[4.4]nonane-2,4-dione Basic information
Product Name:1,3-Diaza-spiro[4.4]nonane-2,4-dione
Synonyms:5,5’-cyclopentanespirohydantoin;5,5-tetramethylenespirohydantoin;ba2839;5,5-TETRAMETHYLENEHYDANTOIN;1,3-diazaspiro[4.4]nonane-2,4-quinone;Hydantoin-5-spirocyclopentane;NSC 1024;Spiro[cyclopentane-1,5'-hydantoin]
CAS:699-51-4
MF:C7H10N2O2
MW:154.17
EINECS:
Product Categories:
Mol File:699-51-4.mol
1,3-Diaza-spiro[4.4]nonane-2,4-dione Structure
1,3-Diaza-spiro[4.4]nonane-2,4-dione Chemical Properties
Melting point 204-205℃
density 1.31
storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear
form powder
pka10.46±0.20(Predicted)
color white to beige
AppearanceWhite to off-white Solid
InChIInChI=1S/C7H10N2O2/c10-5-7(3-1-2-4-7)9-6(11)8-5/h1-4H2,(H2,8,9,10,11)
InChIKeyJTTFXYHJDZZDQK-UHFFFAOYSA-N
SMILESN1C2(CCCC2)C(=O)NC1=O
Safety Information
HS Code 2933998090
MSDS Information
1,3-Diaza-spiro[4.4]nonane-2,4-dione Usage And Synthesis
UsesNon-toxic spiro-hydantoin, reverses plant vernalization epigenetically by reducing H3K27me3 at FLC, enabling heat-free control over flowering time.
DVR06, identified in Arabidopsis thaliana, induces devernalization, reversing the vernalized state at ambient temperatures. Its core function is reactivating the floral repressor FLC within the nucleus, notably in vascular and meristematic tissues. Mechanistically, DVR06 reduces repressive H3K27me3 histone methylation at the FLC locus and other genomic sites, while leaving active H3K4me3 marks unchanged. This epigenetic modulation delays flowering time and enhances vegetative growth. Possessing low toxicity and key hydantoin/spiro pharmacophores, DVR06 serves as a valuable chemical probe for epigenetic memory and holds potential for agricultural control over plant life cycles.
1,3-Diaza-spiro[4.4]nonane-2,4-dione Preparation Products And Raw materials
Preparation ProductsMethyl 1-amino-1-cyclopentanecarboxylate-->Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride
Tag:1,3-Diaza-spiro[4.4]nonane-2,4-dione(699-51-4) Related Product Information
2-(2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl)ethanesulfonyl fluoride 1,3-Diaza-spiro[4.4]nonane-2,4-dione 3-(2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl)propanenitrile 3-Amino-1,3-diazaspiro[4.4]nonane-2,4-dione (2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl)acetic acid 7,7-Dimethyl-2',5'-dioxo-1H-spiro[bicyclo[2.2.1]heptane-2,4'-imidazolidine]-1-carboxylic acid 3-(2,4-Dioxo-1,3-diaza-spiro[4.4]non-3-yl)-propionic acid 4-(2,4-Dioxo-1,3-diaza-spiro[4.4]non-3-yl)-butyric acid 1,7,7-Trimethyl-2',5'-dioxo-4H-spiro[bicyclo[2.2.1]heptane-2,4'-imidazolidine]-4-carboxylic acid Spiriprostil 3-(2-aminoethyl)-1,3-diazaspiro[4.4]nonane-2,4-dione 3-(2-amino-3,3-dimethylbutyl)-1,3-diazaspiro[4.4]nonane-2,4-dione cypenhymustine 3-(3-amino-2-hydroxypropyl)-1,3-diazaspiro[4.4]nonane-2,4-dione 3-(3-chloropropyl)-1,3-diazaspiro[4.4]nonane-2,4-dione