K-252C manufacturers
- K-252c
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- $853.00
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2026-07-16
- CAS:85753-43-1
- Purity:
- Supply Ability: 10g
- K-252c
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- $1230.00
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2025-12-22
- CAS:85753-43-1
- Purity:
- Supply Ability: 10g
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| Product Name: | K-252C | | Synonyms: | K-252C;STAUROSPORINE AGLYCONE;Staurosporinone;Staurosporine Aglycone >99%;Staurosporinone, K-252c;K-252c(Staurosporinone);K252c / Staurosporine Aglycone>99%/ Staurosporinone, K-252C /
6,7,12,13-Tetrahydro-5H-Indolo[2,3-A]Pyrrolo[3,4-C]Carbazol-5-One;K252c, Ready Made Solution | | CAS: | 85753-43-1 | | MF: | C20H13N3O | | MW: | 311.34 | | EINECS: | | | Product Categories: | Inhibitor | | Mol File: | 85753-43-1.mol |  |
| | K-252C Chemical Properties |
| Melting point | >200°C (dec.) | | storage temp. | −20°C | | solubility | DMSO: 10 mg/mL, soluble | | form | solid | | color | Pale Brown to Light Brown | | Water Solubility | Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water. | | InChI | InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24) | | InChIKey | MEXUTNIFSHFQRG-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC=C2)C2=C1C1NC3=C(C=1C1CNC(=O)C=12)C=CC=C3 |
| Safety Statements | 22-24/25 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | K-252C Usage And Synthesis |
| Uses | Inhibits protein kinase C | | Biological Activity | Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV). | | storage | -20°C | | references | 1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819. |
| | K-252C Preparation Products And Raw materials |
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