3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

Request For Quotation
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Suppliers list
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS:552-54-5
Purity:HPLC>=99% Package:5mg
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS: 552-54-5
Purity:99% Package:1KG;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569266 +86-17392581500
Email: 1015@dideu.com
Products Intro: Product Name:3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS:552-54-5
Purity:99.0% Package:100g;1kg;5kg;25kg
Company Name: Hubei Ipure Biology Co., Ltd
Tel: +8613367258412
Email: ada@ipurechemical.com
Products Intro: Product Name:Rhamnazin
CAS:552-54-5
Purity:0.99 Package:5KG;1KG
Company Name: HONG KONG IPURE BIOLOGY CO.,LIMITED
Tel: 86 18062405514 18062405514
Email: ada@ipurechemical.com
Products Intro: Product Name:Rhamnazin
CAS:552-54-5
Purity:.99 Package:5KG;1KG

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE manufacturers
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Basic information
Product Name:3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
Synonyms:rhamnacene;7,3'-DiMethylquercetin;NSC 678106;Quercetin 7,3'-DiMethyl Ether;RhaMnacine;RHAMNAZIN(SH);3,7-DIMETHYLQUERCETIN;3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS:552-54-5
MF:C17H14O7
MW:330.29
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:552-54-5.mol
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Structure
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties
Melting point 214-215 °C
Boiling point 591.6±50.0 °C(Predicted)
density 1.507±0.06 g/cm3(Predicted)
form powder
pka6.14±0.40(Predicted)
BRN 338203
InChIInChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-10(18)12(5-8)23-2/h3-7,18-19,21H,1-2H3
InChIKeyMYMGKIQXYXSRIJ-UHFFFAOYSA-N
SMILESC1(C2=CC=C(O)C(OC)=C2)OC2=CC(OC)=CC(O)=C2C(=O)C=1O
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Usage And Synthesis
UsesDi-O-methylated flavanol; a polyphenolic metabolite of Rhamnus disperma.
DefinitionChEBI: A dimethoxyflavone that is quercetin in which the hydroxy groups at the 3' and 7 positions have been replaced by methoxy groups.
in vivo

Rhamnazin (200 mg/kg; i.g.; daily for 25 days) inhibits breast cancer growth and angiogenesis in mice[1].
Rhamnazin (5-20 mg/kg; i.p.; once) shows strong antioxidant and anti-inflammatory properties in the rat acute lung injury model[2].

Animal Model:BALB/c nude mice, breast cancer xenograft model[1]
Dosage:200 mg/kg
Administration:Intragastric administration, daily for 25 days
Result:Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3.
IC 50VEGFR2: 4.68 μM (IC50)
Tag:3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE(552-54-5) Related Product Information