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| | BRYOSTATIN 2 Basic information |
| Product Name: | BRYOSTATIN 2 | | Synonyms: | BRYO 2;BRYOSTATIN 2;2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-tetrahydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en-12-yl est;7-O-Deacetylbryostatin 1;(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoic acid ester;2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, (2E,4E)- | | CAS: | 87745-28-6 | | MF: | C45H66O16 | | MW: | 863 | | EINECS: | | | Product Categories: | activator | | Mol File: | 87745-28-6.mol |  |
| | BRYOSTATIN 2 Chemical Properties |
| Boiling point | 957.2±65.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at -20 | | solubility | Soluble in ethanol | | form | film | | pka | 11.11±0.70(Predicted) | | color | colorless to light yellow | | biological source | Bugula neritina (sponge) | | InChIKey | LIPGUSBNMQRYNL-WZYRAJGLSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | BRYOSTATIN 2 Usage And Synthesis |
| Uses | Bryostatin 2 is a macrocyclic lactone and antagonist of phorbol ester action. It binds to and activates protein kinase C (PKC) creating a transcriptional response similar to phorbol esters. | | Definition | ChEBI: Bryostatin 2 is a member of the class of bryostatins that is bryostatin 1 in which the acetoxy group has been replaced by a hydroxy group. It has a role as a protein kinase C agonist, an antineoplastic agent and a marine metabolite. It is a member of bryostatins, a cyclic hemiketal, an enoate ester, a methyl ester, an organic heterotetracyclic compound and a secondary alcohol. | | Biological Activity | Bryostatin 2 is potent protein kinase C activator (Ki = 5.9 nM) and an antagonist to phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA). Bryostatin 2 exhibits antineoplastic activity against the murine P388 lymphocytic leukemia and human U937 cells. |
| | BRYOSTATIN 2 Preparation Products And Raw materials |
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