- 2,3,5,6-Tetrafluoropyridine
-
- $5.00 / 1KG
-
2025-09-25
- CAS:2875-18-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
|
| Product Name: | 2,3,5,6-Tetrafluoropyridine | | Synonyms: | 2,3,5,6-TETRAFLUOROPYRIDINE;2,3,5,6-Tetrafluoropyridine 98%;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-TetrafL;2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH | | CAS: | 2875-18-5 | | MF: | C5HF4N | | MW: | 151.06 | | EINECS: | 622-979-9 | | Product Categories: | Fluorine series;Pyridine;Heterocyclic Compounds;Fluoropyridines;Halopyridines;C5;Heterocyclic Building Blocks;Pyridines | | Mol File: | 2875-18-5.mol |  |
| | 2,3,5,6-Tetrafluoropyridine Chemical Properties |
| Boiling point | 102 °C (lit.) | | density | 1.499 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.4046(lit.) | | Fp | 87 °F | | storage temp. | Inert atmosphere,2-8°C | | pka | -10.94±0.20(Predicted) | | form | clear liquid | | color | Colorless to Light yellow | | Specific Gravity | 1.52 | | InChI | InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H | | InChIKey | HWIPMBCMGVXOKN-UHFFFAOYSA-N | | SMILES | C1(F)=NC(F)=C(F)C=C1F | | CAS DataBase Reference | 2875-18-5(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, 2,3,5,6-tetrafluoro-(2875-18-5) |
| Hazard Codes | Xi,F,C | | Risk Statements | 10-36/37/38 | | Safety Statements | 28-36 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | Hazard Note | Flammable/Irritant | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 2,3,5,6-Tetrafluoropyridine Usage And Synthesis |
| Synthesis | Catalytic reduction of aryl chlorides, bromides and iodides is well documented,
however, aryl fluorides do not readily react under these conditions, owing to the strong
C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6-
tetrafluoropyridine using a palladium catalyst.
 | | Preparation | An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g, 118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm3) and heated at 200 ℃ for 48 h. The mixture was added to water and extracted into ether. The ether solution was shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by comparison of their GCMS and fluorine nmr spectra with authentic samples. | | Application | 2,3,5,6-Tetrafluoropyridine is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in organic synthesis processes and chemical and pharmaceutical synthesis processes in laboratory research and development. | | Description | Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.
| | Chemical Properties | clear colorless liquid | | Uses | 2,3,5,6-Tetrafluoropyridine is a fluoropyridine compound. The four fluorine atoms on its pyridine ring structure can be used for substitution reactions or as a fluorine source for preparing products such as battery materials. |
| | 2,3,5,6-Tetrafluoropyridine Preparation Products And Raw materials |
| Raw materials | Pyridine, 2,3,5,6-tetrafluoro-4-(trimethylsilyl)--->4,4'-Bipyridine, 2,2',3,3',5,5',6,6'-octafluoro--->FLUOROTRIETHYLSILANE-->4-Bromo-2,3,5,6-tetrafluoropyridine-->Triphenylsilane-->Methyl 4-bromobenzoate-->Pentafluoropyridine | | Preparation Products | 2,5-Difluoropyridine-->2,3,4,6-TETRAFLUOROPYRIDINE-->3,4,5-Trifluoropyridine-->2,3,6-TRIFLUOROPYRIDINE-->2,3,4,5-Tetrafluoropyridine |
|