4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Suppliers list

Company Name:	Shanghai Rochi Pharmaceutical Co.,Ltd.
Tel:	21-38751876 +8615000076078
Email:	info@rochipharma.com
Products Intro:	Product Name:4-(4-aminophenyl)morpholin-3-one CAS:438056-69-0 Purity:99%min Package:1kg 5kg 10kg 25kg

Company Name:	Beijing Mediking Biopharm Co., Ltd
Tel:	+undefined15901403431
Email:	sales01@mediking.cn
Products Intro:	Product Name:4-(4-aminophenyl)morpholin-3-one CAS:438056-69-0 Package:25KG;

Company Name:	Hebei Chuanghai Biotechnology Co., Ltd
Tel:	+8615350571055
Email:	Sibel@chuanghaibio.com
Products Intro:	Product Name:4-(4-AMINOPHENYL)MORPHOLIN-3-ONE CAS:438056-69-0 Purity:99% Package:1KG;10.00;USD

Company Name:	Henan Bao Enluo International TradeCo.，LTD
Tel:	+86-17331933971
Email:	deasea125996@gmail.com
Products Intro:	Product Name:4-(4-AMINOPHENYL)MORPHOLIN-3-ONE CAS:438056-69-0 Purity:99% Package:1kg;10USD

Company Name:	Anhui Ruihan Technology Co., Ltd
Tel:	+8617756083858
Email:	daisy@anhuiruihan.com
Products Intro:	Product Name:4-(4-Aminophenyl)morpholin-3-one CAS:438056-69-0 Purity:99% Package:1kg;30USD

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE manufacturers

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Basic information

Product Name:	4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
Synonyms:	Rivaroxaban Intermediate 1;Rivaroxaban InterMediate;4-(4-aMinophenyl) Morpholinone;3-Morpholinone, 4-(4-aminophenyl)-;4-(4-Aminophenyl)morpholin-3-one ,97%;4-(4-AMinophenyl)-3-Morpholinone;4-(3-Oxo-4-Morpholinyl)aniline;4-(3-Oxo-4-Morpholinyl)aniline-d4
CAS:	438056-69-0
MF:	C10H12N2O2
MW:	192.21
EINECS:	610-147-8
Product Categories:	Amines and Anilines;Heterocycles;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Intermediates;Intermediate of Rivaroxaban
Mol File:	438056-69-0.mol

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Chemical Properties

Melting point	171.0 to 175.0 °C
Boiling point	502.3±45.0 °C(Predicted)
density	1.268
vapor pressure	0Pa at 25℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	4.85±0.10(Predicted)
form	Solid
color	White to Light Brown
Water Solubility	16.6g/L at 20℃
Major Application	pharmaceutical
InChI	InChI=1S/C10H12N2O2/c11-8-1-3-9(4-2-8)12-5-6-14-7-10(12)13/h1-4H,5-7,11H2
InChIKey	MHCRLDZZHOVFEE-UHFFFAOYSA-N
SMILES	N1(C2=CC=C(N)C=C2)CCOCC1=O
LogP	-0.8 at 25℃
CAS DataBase Reference	438056-69-0

Safety Information

MSDS Information

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Usage And Synthesis

Chemical Properties	4-(4-AMINOPHENYL)MORPHOLIN-3-ONE is Off-White Solid
Uses	4-(4-AMINOPHENYL)MORPHOLIN-3-ONE is used in the preparation of various Morpholine based pharmaceuticals.
Uses	Rivaroxaban intermediate
Flammability and Explosibility	Non flammable
Synthesis	2-anilinoethanol (11) was condensed with ethyl chloroacetate in the presence of potassium tert-butoxide in tetrahydrofuran to afford the required phenylmorpholinone (12). Nitration of the intermediate morpholinone (12) in a solution of concentrated sulphuric acid with nitric acid below room temperature provided after recrystallization the para-product (13) in > 99.5% HPLC purity. The mother liquor was enriched predominantly with unwanted ortho - and meta-isomers together with depleted para-product. By subsequent hydrogenation of the nitro group in 13 with palladium on charcoal in methanol the 4-(4-Aminophenyl)morpholin-3-one (14) was obtained. [1] W. MEDERSKI; Markus W; P Wendel. Practical and efficient processes for the preparation of 4-(4-aminophenyl)morpholin-3-ones on a larger scale: precursor of factor Xa inhibitors[J]. Heterocycles, 2007, 74 1: 437-445. DOI:10.3987/COM-07-S(W)22.

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Preparation Products And Raw materials

Raw materials

Tag:4-(4-AMINOPHENYL)MORPHOLIN-3-ONE(438056-69-0) Related Product Information

4-(4-NITROPHENYL)MORPHOLIN-3-ONE Rivaroxaban Impurity 43 Rivaroxaban Impurity 34 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- POLYSTYRENE IODOSOACETATE 1,2-Cyclohexanedione 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Rivaroxaban (S)-(+)-Glycidyl Phthalimide 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Rivaroxaban iMpurity 5 (S)-(+)-Epichlorohydrin

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.