- 8-Hydroxyoctanoic acid
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- $0.00 / 25KG
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2024-03-28
- CAS:764-89-6
- Min. Order: 25KG
- Purity: 95%
- Supply Ability: Inquiry
- 8-hydroxyoctanoicacid
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- $0.00 / 1KG
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2022-01-15
- CAS:764-89-6
- Min. Order: 1KG
- Purity: 97.5%
- Supply Ability: 100 tons
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| | 8-HYDROXYOCTANOIC ACID Basic information |
| | 8-HYDROXYOCTANOIC ACID Chemical Properties |
| Melting point | 59-63 °C | | Boiling point | 130°C/1mm | | density | 1.0227 (rough estimate) | | refractive index | 1.4370 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 4.77±0.10(Predicted) | | form | crystalline powder | | color | White | | BRN | 1237092 | | LogP | 0.900 (est) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | F | 10-21 | | HS Code | 2918199890 |
| | 8-HYDROXYOCTANOIC ACID Usage And Synthesis |
| Chemical Properties | light yellow powder | | Uses | 8-Hydroxyoctanoic Acid is an intermediate in the synthesis of mono-carboxy-isooctyl-phthalate (M525590). 8-Hydroxyoctanoic Acid is also used as a reagent in the synthesis of histone deacetylases (HDAC) inhibitors with an N-formyl hydroxylamine head group which are promising targets for cancer chemotherapy. | | Definition | ChEBI: An omega-hydroxy fatty acid that is caprylic acid in which one of the hydrogens of the terminal methyl group is replaced by a hydroxy group. | | General Description | 8-Hydroxyoctanoic acid is one of the constituents of ‘‘Royal jelly′′ acid found in herbhoneys and genuine honeys. | | Synthesis | GENERAL PROCEDURE: All catalytic activity testing experiments were carried out in Schlenk tubes (50 mL) equipped with a condenser. 8-Hydroxycaprylic acid (HCA) was prepared by HDO oxidation reaction in alkaline aqueous medium using H2O2 as oxidant. The typical reaction procedure was as follows: first, the aliphatic diol (0.5 mmol) was weighed and dispersed with catalyst (25 mg) in deionized water (3.5 mL) in a Schlenk tube. Subsequently, 30% H2O2 (0.75 mL) and 0.5 M NaOH (0.75 mL) were added to the above mixture. The Schlenk tubes were placed in an oil bath preheated to 353 K and reacted for different time intervals under continuous magnetic stirring (500 rpm). After completion of the reaction, a portion of the reaction solution was taken and diluted 20-fold with 10 mM aqueous H2SO4 and the catalyst was removed by passing it through a 0.20 μm filter (Milex-LG). The resulting filtrate was analyzed by high performance liquid chromatography (HPLC, WATERS 600) on an Aminex HPX-87H column (Bio-Rad Laboratories, Inc.) with a refractive index detector. An aqueous solution of 10 mM H2SO4 was used as the eluent at a flow rate of 0.5 mL/min, and the column temperature was maintained at 323 K. The conversion and yield were determined by the calibration curve method for commercial products. | | References | [1] Catalysis Today, 2016, vol. 265, p. 231 - 239 |
| | 8-HYDROXYOCTANOIC ACID Preparation Products And Raw materials |
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