- WNK-IN-11
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- $84.00
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2026-07-14
- CAS:2123489-30-3
- Purity: 98.32%
- Supply Ability: 10g
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| | Allosteric WNK Kinase Inhibitor , Basic information |
| Product Name: | Allosteric WNK Kinase Inhibitor , | | Synonyms: | ALLOSTERIC WNK KINASE INHIBITOR;Allosteric WNK Kinase Inhibitor ,;WNK-IN-11;WNK-IN-11; WNK IN 11; WNKIN11; WNK INHIBITOR 11; WNK INHIBITOR-11;2123489-30-3;(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone;Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-;Threonine proteases,inhibit,WNKIN11,Serine proteases,Serine endopeptidases,Inhibitor,Ser/Thr Protease,WNK IN 11;WNK-IN-11, 10 mM in DMSO | | CAS: | 2123489-30-3 | | MF: | C21H21Cl2N5OS | | MW: | 462.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2123489-30-3.mol |  |
| | Allosteric WNK Kinase Inhibitor , Chemical Properties |
| Boiling point | 641.1±65.0 °C(Predicted) | | density | 1.407±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml | | form | A crystalline solid | | pka | 5.52±0.10(Predicted) | | color | White to off-white |
| | Allosteric WNK Kinase Inhibitor , Usage And Synthesis |
| Uses | WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. | | References | [1] Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107. DOI:10.1021/acs.jmedchem.7b00708 |
| | Allosteric WNK Kinase Inhibitor , Preparation Products And Raw materials |
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