19,20-EDP epoxide

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19,20-EDP epoxide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(±)19(20)-EDP Ethanolamide
CAS:2123485-34-5
Package:100μg;
Company Name: BOC Sciences
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:(±)19(20)-EDP Ethanolamide
CAS:2123485-34-5
Purity:>=98% Remarks:Please reach out to us for more information about custom solutions.
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Products Intro: Product Name:(±)19(20)-EDP Ethanolamide
CAS:2123485-34-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:(±)19(20)-EDP Ethanolamide
CAS:2123485-34-5
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:19,20-EDP epoxide
CAS:2123485-34-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g

19,20-EDP epoxide manufacturers
19,20-EDP epoxide Basic information
Product Name:19,20-EDP epoxide
Synonyms:19,20-EDP epoxide;(±)19(20)-EDP Ethanolamide;4,7,10,13,16-Octadecapentaenamide, 18-(3-ethyl-2-oxiranyl)-N-(2-hydroxyethyl)-, (4Z,7Z,10Z,13Z,16Z)-;(±)19(20)-EDP Ethanolamide
CAS:2123485-34-5
MF:C24H37NO3
MW:387.56
EINECS:
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Mol File:2123485-34-5.mol
19,20-EDP epoxide Structure
19,20-EDP epoxide Chemical Properties
storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
Safety Information
MSDS Information
19,20-EDP epoxide Usage And Synthesis
Description(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; ) by cytochrome P450 (CYP) epoxygenases.1,2 (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells.2 It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-2 microglia stimulated by LPS and decreases LPS-induced cytotoxicity when used at concentrations ranging from 5 to 10 μM. It also decreases nitrite production when used at a concentration of 7.5 μM, an effect that can be partially reversed by the CB2 receptor antagonist AM630 and the PPARγ antagonist GW 9662 . (±)19(20)-EDP ethanolamide induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 μM) and reduces tube formation by human microvascular endothelial cells (HMVECs) in a Matrigel assay.
Uses(±)19(20)-EDP ethanolamide (19,20-DHEA epoxide) (compound 19) is an ω-3 endocannabinoid epoxide with cytokine modulation in neuroinflammation studies, antiangiogenic effects in vascular endothelial cells, and vasodilatory effects on coronary arteries.
References1. McDougle, D.R., Watson, J.E., Abdeen, A.A., et al. Anti-inflammatory ω-3 endocannabinoid epoxides Proc. Natl. Acad. Sci. USA 114(30),E6034-E6043(2017).
2. Roy, J., Watson, J.E., Hong, I.S., et al. Antitumorigenic properties of omega-3 endocannabinoid epoxides J. Med. Chem. 61(13),5569-5579(2018).
19,20-EDP epoxide Preparation Products And Raw materials
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