| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:Leukotriene C4-d5 methyl ester
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Leukotriene C4-d5 methyl ester
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:Leukotriene C4-d5 methyl ester
|
| Company Name: |
Boao Pike
|
| Tel: |
010-57798038 15652371397 |
| Email: |
lyn@biopike.com.cn |
| Products Intro: |
Product Name:Leukotriene C4-d5 methyl ester
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| | Leukotriene C4-d5 methyl ester Basic information |
| | Leukotriene C4-d5 methyl ester Chemical Properties |
| solubility | DMF: 50 mg/ml
DMSO: 50 mg/ml
Ethanol: 1 mg/ml
Ethanol: H20 (95:5): 2 mg/mlPBS (pH 7.2): 0.1 mg/ml |
| | Leukotriene C4-d5 methyl ester Usage And Synthesis |
| Description | Leukotriene C4-d5 (LTC4-d5) methyl ester is intended for use as an internal standard for the quantification of LTC4 methyl ester by GC- or LC-MS. LTC4 is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.1 It is one of the constituents of slow-reacting substance of anaphylaxis and exhibits potent smooth muscle contracting activity.2 LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.3,4 The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.4 LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.WARNING This product is not for human or veterinary use. | | References | [1] J A MACLOUF R C M. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.[J]. The Journal of Biological Chemistry, 1988, 263 1: 174-181.
[2] PIPER P J. Formation and actions of leukotrienes.[J]. Physiological reviews, 1984, 64 2: 744-761. DOI: 10.1152/physrev.1984.64.2.744
[3] MALMSTEN C L. Leukotrienes: mediators of inflammation and immediate hypersensitivity reactions.[J]. Critical Reviews in Immunology, 1984, 4 4: 307-334.
[4] LEFER A M. Leukotrienes as mediators of ischemia and shock[J]. Biochemical pharmacology, 1986, 35 2: Pages 123-127. DOI: 10.1016/0006-2952(86)90502-2
[5] TRAN THI VAN ANH . From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution[J]. Acta Pharmaceutica Sinica. B, 2021, 11 6: Pages 1629-1647. DOI: 10.1016/j.apsb.2021.04.011 |
| | Leukotriene C4-d5 methyl ester Preparation Products And Raw materials |
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