PF-6808472

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Company Name: Sigma-Aldrich  
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PF-6808472 manufacturers

  • PF-6808472
  • PF-6808472 pictures
  • $455.00
  • 2026-07-27
  • CAS:2088112-70-1
  • Purity: 99.02%
  • Supply Ability: 10g
PF-6808472 Basic information
Product Name:PF-6808472
Synonyms:PF-6808472;Benzenesulfonyl fluoride, 4-[[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-[(2-propyn-1-ylamino)carbonyl]-2-pyrimidinyl]-1-piperazinyl]methyl]-;4-((4-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-6-(prop-2-yn-1-ylcarbamoyl)pyrimidin-2-yl)piperazin-1-yl)methyl)benzenesulfonyl fluoride;XO44
CAS:2088112-70-1
MF:C25H27FN8O3S
MW:538.6
EINECS:
Product Categories:
Mol File:2088112-70-1.mol
PF-6808472 Structure
PF-6808472 Chemical Properties
density 1.452±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: 5mg/mL, clear (warmed)
form powder
pka11.23±0.46(Predicted)
color white to beige
InChIKeyZBSPMOBILDLOCV-UHFFFAOYSA-N
SMILESF[S](=O)(=O)c1ccc(cc1)CN2CCN(CC2)c3nc(cc(n3)C(=O)NCC#C)Nc4n[nH]c(c4)C5CC5
Safety Information
RIDADR UN 3265 8 / PGII
WGK Germany WGK 3
Storage Class8A - Combustible corrosive hazardous materials
Hazard ClassificationsEye Dam. 1
Skin Corr. 1B
MSDS Information
PF-6808472 Usage And Synthesis
UsesXO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2].
Biochem/physiol ActionsPF-6808472 is a cell permeable covalent probe suitable for click chemistry designated to measure kinase selectivity in intact cells. PF-6808472 contains sulfonyl fluoride group, which react with conserved lysine residue within kinase ATP binding site.
IC 50CDK4; CDK1; CDK2
References[1] Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. DOI:10.1021/acs.jmedchem.1c00159
[2] Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366(6471):eaaw2106. DOI:10.1126/science.aaw2106
PF-6808472 Preparation Products And Raw materials
Tag:PF-6808472(2088112-70-1) Related Product Information
N-(5-(difluoromethoxy)-1H-pyrazol-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazolo[3,4-b]pyrazin-6-amine CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) GSK-3326595 Anti-Aging Compound Library CDK2 Protein, HUMAN (HIS)