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8-Hydroxymethyl guanosine manufacturers
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| | 8-Hydroxymethyl guanosine Basic information |
| Product Name: | 8-Hydroxymethyl guanosine | | Synonyms: | 8-Hydroxymethyl guanosine;Guanosine, 8-(hydroxymethyl)-;2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-(hydroxymethyl)-1,9-dihydro-6H-purin-6-one | | CAS: | 54898-41-8 | | MF: | C11H15N5O6 | | MW: | 313.27 | | EINECS: | | | Product Categories: | | | Mol File: | 54898-41-8.mol |  |
| | 8-Hydroxymethyl guanosine Chemical Properties |
| density | 2.25±0.1 g/cm3(Predicted) | | pka | 9.61±0.20(Predicted) |
| | 8-Hydroxymethyl guanosine Usage And Synthesis |
| Uses | 8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
| | 8-Hydroxymethyl guanosine Preparation Products And Raw materials |
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