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BOC Sciences
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1-631-485-4226; 16314854226 |
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| Products Intro: |
Product Name:BPKDi
CAS:1201673-28-0
Purity:99% Remarks:Reach out to us for more information about custom solutions.
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BPKDi manufacturers
- BPKDi
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- $2390.00 / 10mg
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2026-03-12
- CAS:1201673-28-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | BPKDi | | Synonyms: | BPKDi;[2,4'-Bipyridine]-4-carboxamide, 2'-(cyclohexylamino)-6-(1-piperazinyl)-;2′-(Cyclohexylamino)-6-(1-piperazinyl)[2,4′-bipyridine]-4-carboxamide | | CAS: | 1201673-28-0 | | MF: | C21H28N6O | | MW: | 380.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1201673-28-0.mol |  |
| | BPKDi Chemical Properties |
| Boiling point | 633.1±55.0 °C(Predicted) | | density | 1.226±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 14.86±0.50(Predicted) | | color | Off-white to light yellow |
| | BPKDi Usage And Synthesis |
| Uses | BPKDi is a potent bipyridyl PKD inhibitor with IC50s of 1 nM, 9 nM and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes[1]. | | Biological Activity | BPKDi is an inhibitor of protein kinase D (PKD; IC50s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively).1 It is selective for PKD over PKCδ and PKCε, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 μM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 μM. | | IC 50 | PKD1: 1 nM (IC50); PKD2: 9 nM (IC50); PKD3: 1 nM (IC50) | | References | 1.Monovich, L., Vega, R.B., Meredith, E., et al.A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinaseFEBS Lett.584(3)631-637(2010) |
| | BPKDi Preparation Products And Raw materials |
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