11B-羟孕酮
| 中文名称 | 11B-羟孕酮 |
|---|---|
| 中文同义词 | 11B-羟孕酮;11Β-羟基-4-孕烯-3,20-二酮;11Β-羟基孕-4-烯-3,20-二酮;11Β-羟孕酮, >98%;11Β-羟孕酮(溶液);11Β-羟孕酮;11Β-羟基黄体酮;化合物 TCA2511 |
| 英文名称 | 11BETA-HYDROXYPROGESTERONE |
| 英文同义词 | 11-beta-hydroxy-pregn-4-ene-20-dione;11-beta-hydroxypregn-4-ene-3,20-dione;11-hydroxy-20-dion(11-beta)-pregn-4-ene-;Pregn-4-ene-3,20-dione,11-hydroxy-, (11b)-;11beta-Hydroxyprogesterone, >98%;21-deoxycorticosterone;HYDROXYPROGESTERONE, 11B-;17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| CAS号 | 600-57-7 |
| 分子式 | C21H30O3 |
| 分子量 | 330.46 |
| EINECS号 | 209-995-8 |
| 相关类别 | 标准品 -中药标准品;Steroids |
| Mol文件 | 600-57-7.mol |
| 结构式 |  |
11B-羟孕酮 性质
| 熔点 | 181～184℃ |
|---|---|
| 沸点 | 487.4±45.0 °C(Predicted) |
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于丙酮（少许）、氯仿（少许）、甲醇（少许） |
| 酸度系数(pKa) | 14.52±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | 30.84mg/L(37 ºC) |
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Human Endogenous Metabolite
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11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED 50 of 10 nM and stimulates Ams/ sc in mpkCCD cl4 cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770.
11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors.