EOAI3402143 manufacturers
- EOAI3402143
-
- $61.00
-
2026-07-27
- CAS:1699750-95-2
- Purity: 99.60%
- Supply Ability: 10g
- EOAI3402143
-
- $61.00
-
2026-07-27
- CAS:1699750-95-2
- Purity: 99.60%
- Supply Ability: 10g
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| | EOAI3402143 Basic information |
| Product Name: | EOAI3402143 | | Synonyms: | EOAI3402143;EOAI3402143
(Deubiquitinase inhibitor G9;2-Propenamide, 2-cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-, (2E)-;(2E)-2-Cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-2-propenamide;EOAI3402143Tosylate;(E)-2-Cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide;Inhibitor,Deubiquitinase,DUBs,inhibit,EOAI3402143,EOAI 3402143,EOAI-3402143;EOAI3402143 ，S6877 | | CAS: | 1699750-95-2 | | MF: | C25H28Cl2N4O3 | | MW: | 503.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1699750-95-2.mol |  |
| | EOAI3402143 Chemical Properties |
| Boiling point | 711.2±60.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:75.0(Max Conc. mg/mL);148.98(Max Conc. mM) | | form | Solid | | pka | 10.73±0.46(Predicted) | | color | Light yellow to yellow |
| | EOAI3402143 Usage And Synthesis |
| Uses | EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. | | in vivo | To examine this potential, the effect of EOAI3402143 (G9) treatment is investigated on human MIAPACA2 tumor xenografts. Human MIAPACA2 cells are injected subcutaneously into NSG mice. Primary tumor development is monitored by caliper measurements, and once measurable, mice are separated into two groups and are treated with either vehicle control (PEG300/DMSO) or G9 at 15 mg/kg. Tumor growth, animal weight, behavior, and mobility are monitored during treatment. In parallel, murine 8041 tumors are also established and subjected to similar G9 treatment and tumor monitoring regimen as the human MIAPACA2 xenografts. Consistent with the in vitro findings, Usp9x inhibition results in the suppression of tumor growth in human tumor xenografts, but any significant effect on the growth of 8041 tumors xenografts is not observed, although the Usp9x activity is inhibited effectively by EOAI3402143 treatment in both human MIAPACA2 and mouse 8041 xenograft tumors[3]. | | References | [1] Potu H, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 2014 Jul 30;5(14):5559-69. DOI:10.18632/oncotarget.2140
[2] Peterson LF, et al. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. 2015 Jun 4;125(23):3588-97. DOI:10.1182/blood-2014-10-605584
[3] Pal A, et al. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia. 2018 Feb;20(2):152-164. DOI:10.1016/j.neo.2017.11.007 |
| | EOAI3402143 Preparation Products And Raw materials |
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