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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) manufacturers
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| | Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Basic information |
| Product Name: | Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) | | Synonyms: | Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate;D4-Vilanterol Triphenylacetic Acid Salt | | CAS: | 2021249-10-3 | | MF: | C44H49Cl2NO7 | | MW: | 774.78 | | EINECS: | | | Product Categories: | | | Mol File: | 2021249-10-3.mol |  |
| | Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties |
| solubility | DMF: soluble; DMSO: soluble; Methanol: soluble | | form | A solid |
| | Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Usage And Synthesis |
| Description | Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC50 = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. | | Uses | Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively. | | References | 1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach J. Med. Chem. 53(11),4522-4530(2010). |
| | Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials |
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