Norbinaltorphimine Dihydrochloride
| 中文名称 | Norbinaltorphimine Dihydrochloride |
|---|---|
| 中文同义词 | 化合物 T12241;NOR-BINALTORPHIMINE (NOR-BNI),KAPPA OPIOID RECEPTOR拮抗剂;去甲双氢吗啡盐酸盐 |
| 英文名称 | Norbinaltorphimine Dihydrochloride |
| 英文同义词 | (1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol;nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist;nor-Binaltorphimine dihydrochloride |
| CAS号 | 113158-34-2 |
| 分子式 | C40H44ClN3O6 |
| 分子量 | 698.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 113158-34-2.mol |
| 结构式 |  |
Norbinaltorphimine Dihydrochloride 性质
| 熔点 | >280 °C (decomp) |
|---|---|
| 储存条件 | Store at RT |
| 溶解度 | 温和加热下在水中的溶解度为 25 mM，在 DMSO 中的溶解度为 25 mM |
| 形态 | 粉末 |
| 颜色 | 浅黄至灰色 |
| InChIKey | JOJPJLHRMGPDPV-LZQROVCBSA-N |
| SMILES | Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13 |
κ opioid receptor
Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.
Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100903 | Norbinaltorphimine Dihydrochloride Norbinaltorphimine dihydrochloride | 113158-34-2 | 5 mg | 950元 |
| 2026/06/05 | HY-100903 | Norbinaltorphimine Dihydrochloride Norbinaltorphimine dihydrochloride | 113158-34-2 | 10 mg | 1500元 |