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| Product Name: | Aloin | | Synonyms: | 9(10H)-Anthracenone, 10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-;10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone | | CAS: | 452311-56-7 | | MF: | C21H22O9 | | MW: | 418.4 | | EINECS: | | | Product Categories: | | | Mol File: | 452311-56-7.mol |  |
| | Aloin Chemical Properties |
| Boiling point | 752.6±60.0 °C(Predicted) | | density | 1.647±0.06 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 0.5 mg/ml | | form | A crystalline solid | | pka | 7.12±0.40(Predicted) |
| | Aloin Usage And Synthesis |
| Description | Aloin is a mixture of aloin A and aloin B , anthraquinones found in Aloe vera, and has diverse biological activities. It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM. Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg. Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer. | | Definition | ChEBI: Aloin is a diastereoisomeric mixture of aloin A (barbaloin) and aloin B (isobarbaloin), which have similar properties. It is a bitter-tasting, yellow-brown colored compound found in the exudate of at least 68 Aloe species at levels of up to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 species at indeterminate levels. It is used as a stimulant-laxative, treating constipation by inducing bowel movements. It has a role as a laxative and an EC 1.14.18.1 (tyrosinase) inhibitor. It contains an aloin A and an aloin B. | | References | [1] XUAN LUO. Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB.[J]. Molecules, 2018. DOI: 10.3390/molecules23030517
[2] YITAGESU TEWABE. Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolate.[J]. BMC Veterinary Research, 2014: 61. DOI: 10.1186/1746-6148-10-61
[3] O O HAMIZA. Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats.[J]. Human & Experimental Toxicology, 2014, 33 2: 148-163. DOI: 10.1177/0960327113493307 |
| | Aloin Preparation Products And Raw materials |
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