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| | Stearoyl-L-carnitine-d3 (chloride) Basic information |
| Product Name: | Stearoyl-L-carnitine-d3 (chloride) | | Synonyms: | Stearoyl-L-carnitine-d3 (chloride);(R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(stearoyloxy)propan-1-aminium,monochloride;O-Octadecanoyl-L-carnitine-d3 Hydrochloride;Stearyl-L-Carnitine-D3 hydrochloride;O-Octadecanoy-L-Carnitine-D3 Hydrochloride;Octadecanoyl-L-carnitine-d3 (N-methyl-d3) hydrochloride;L-Carnitine·HCl, ??-octadecanoyl (??-methyl-D?, 98%);Octadecanoyl Carnitine-D3 Hcl (Standard) | | CAS: | 2245711-27-5 | | MF: | C25H45ClD3NO3 | | MW: | 449.125005334 | | EINECS: | | | Product Categories: | | | Mol File: | 2245711-27-5.mol |  |
| | Stearoyl-L-carnitine-d3 (chloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml | | form | A solid | | color | White to light yellow | | Appearance | white solid | | Stability: | Hygroscopic | | InChI | 1S/C26H51NO3.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(28)21-24(22-26(29)30)23-27(2,3)4;/h24H,5-23H2,1-4H3;1H/t24-;/m1./s1/i2D3; | | InChIKey | FHYDBUBEZJDPMT-CVTUNGPQSA-N | | SMILES | [O-]C(C[C@@H](CC(CCCCCCCCCCCCCCCCC)=O)C[N+](C)(C([2H])([2H])[2H])C)=O.Cl |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Stearoyl-L-carnitine-d3 (chloride) Usage And Synthesis |
| Description | Stearoyl-L-carnitine-d3 (chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine (Item No. 26556) by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. It inhibits sodium-dependent [3H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM. It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 μM. Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease. | | Uses | Stearoyl-L-carnitine-d3 Hydrochloride is labelled Stearoyl Carnitine (S686515), A carnitine ester which was tested for its ability to inhibit protein kinase C (PKC). | | IC 50 | GlyT2 | | References | [1] WEI HUANG . Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells[J]. Biochemical pharmacology, 1999, 58 8: Pages 1361-1370. DOI: 10.1016/s0006-2952(99)00219-1
[2] BELL F P. Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)[J]. International Journal of Biochemistry, 1983, 15 2: Pages 133-136. DOI: 10.1016/0020-711x(83)90053-8 |
| | Stearoyl-L-carnitine-d3 (chloride) Preparation Products And Raw materials |
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