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Product Name:3-beta-C-Ethynylguanosine
CAS:180300-56-5
Purity:98% Package:按需包装
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3'-beta-C-Ethynylguanosine manufacturers
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| | 3'-beta-C-Ethynylguanosine Basic information |
| Product Name: | 3'-beta-C-Ethynylguanosine | | Synonyms: | 3'-beta-C-Ethynylguanosine;3'-?C-Ethynylguanosine;3’-β-C-Ethynylguanosine;Guanosine, 3'-C-ethynyl- (9CI);3'-C-Ethynylguanosine;3’-beta-C-Ethynylguanosine;2-amino-9-((2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one | | CAS: | 180300-56-5 | | MF: | C12H13N5O5 | | MW: | 307.26 | | EINECS: | | | Product Categories: | | | Mol File: | 180300-56-5.mol |  |
| | 3'-beta-C-Ethynylguanosine Chemical Properties |
| density | 1.89±0.1 g/cm3(Predicted) | | pka | 9+-.0.20(Predicted) |
| | 3'-beta-C-Ethynylguanosine Usage And Synthesis |
| Uses | 3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
| | 3'-beta-C-Ethynylguanosine Preparation Products And Raw materials |
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