CM03
(G-quadruplex binder CM03) manufacturers
- CM03
-
-
2026-05-11
- CAS:2101208-44-8
- Purity: 98.65%
- Supply Ability: 10g
|
| | CM03
(G-quadruplex binder CM03) Basic information |
| Product Name: | CM03
(G-quadruplex binder CM03) | | Synonyms: | CM03
(G-quadruplex binder CM03);CM03;Benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, 2,7-bis[3-(4-morpholinyl)propyl]-4-[[2-(1-pyrrolidinyl)ethyl]amino]- | | CAS: | 2101208-44-8 | | MF: | C34H44N6O6 | | MW: | 632.75 | | EINECS: | | | Product Categories: | | | Mol File: | 2101208-44-8.mol |  |
| | CM03
(G-quadruplex binder CM03) Chemical Properties |
| Boiling point | 822.4±65.0 °C(Predicted) | | density | 1.321±0.06 g/cm3(Predicted) | | pka | 9.86±0.20(Predicted) | | form | Solid | | color | Brown to dark brown |
| | CM03
(G-quadruplex binder CM03) Usage And Synthesis |
| Description | CM03 is a potent inhibitor of cell growth in PDAC cell lines, and has anticancer activity in PDAC models, with a superior profile compared to gemcitabine, a commonly used therapy. Whole-transcriptome RNA-seq methodology has been used to analyze the effects of this quadruplexbinding small molecule on global gene expression. This has revealed the down-regulation of a large number of genes, rich in putative quadruplex elements and involved in essential pathways of PDAC survival, metastasis, and drug resistance. The changes produced by CM03 represent a global response to the complexity of human PDAC and may be applicable to other currently hard-to-treat cancers. | | Uses | CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells[1][2]. | | References | [1] Ahmed AA, et al. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Molecules. 2020 Nov 19;25(22):5407. DOI:10.3390/molecules25225407
[2] Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. DOI:10.1021/acsmedchemlett.0c00317 |
| | CM03
(G-quadruplex binder CM03) Preparation Products And Raw materials |
|