Deltazinone manufacturers
- Deltazinone
-
- $2500.00
-
2026-05-11
- CAS:894554-89-3
- Purity:
- Supply Ability: 10g
|
| | Deltazinone Basic information |
| Product Name: | Deltazinone | | Synonyms: | Deltazinone 1
(Deltazinone1);6H-Pyrazolo[3,4-d]pyridazine-6-butanamide, 2,7-dihydro-3,4-dimethyl-2-(4-methylphenyl)-7-oxo-N-(2-phenylpropyl)-;Deltazinone | | CAS: | 894554-89-3 | | MF: | C27H31N5O2 | | MW: | 457.57 | | EINECS: | | | Product Categories: | | | Mol File: | 894554-89-3.mol |  |
| | Deltazinone Chemical Properties |
| | Deltazinone Usage And Synthesis |
| Description | Deltazinone is highly potent and selective PDEδ inhibitor. Deltazinone exhibits less unspecific cytotoxicity than the previously reported Deltarasin and demonstrates a high correlation with the phenotypic effect of PDEδ knockdown in a set of human pancreatic cancer cell lines. | | Uses | Deltazinone 1, a pyrazolopyridazinone, is a highly selective PDEδ inhibitor with a KD of 8nM. Deltazinone 1 inhibits the PDEδ-Ras interaction. Deltazinone 1 shows a dose-dependent inhibitory response on proliferation in oncogenic KRas-dependent cell lines[1][2]. | | IC 50 | PDEδ: 8 nM (Kd) | | References | [1] Bjrn Papke, et al. Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun. 2016 Apr 20;7:11360. DOI:10.1038/ncomms11360
[2] Pablo Martín-Gago, et al. Structure-based development of PDEδ inhibitors. Biol Chem. 2017 May 1;398(5-6):535-545. DOI:10.1515/hsz-2016-0272 |
| | Deltazinone Preparation Products And Raw materials |
|