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BOC Sciences |
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16314854226; +8616314854226 |
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inquiry@bocsci.com |
Foliglurax hydrochloride manufacturers
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| | Foliglurax hydrochloride Basic information |
| | Foliglurax hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 5 mg/mL (10.92 mM) | | form | Solid | | color | Light yellow to yellow |
| | Foliglurax hydrochloride Usage And Synthesis |
| Uses | Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM[1]. Antiparkinsonian effect[1]. | | IC 50 | mGlu4: 79 nM (EC50) | | References | [1] Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. DOI:10.1021/acs.jmedchem.7b00991
[2] Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. DOI:10.1080/17460441.2018.1443076 |
| | Foliglurax hydrochloride Preparation Products And Raw materials |
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