N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide CAS#: 154563-54-9

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

生物活性体外研究体内研究用途与合成方法 MSDS N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide价格(试剂级) 上下游产品信息

中文名称	N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
中文同义词	化合物 T24816;化合物SP-100030;N-(3,5-双(三氟甲基)苯基)-2-氯-4-(三氟甲基)嘧啶-5-甲酰胺;化合物SP-100030,10 MM DMSO 溶液
英文名称	N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
英文同义词	N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide;SP 100030;5-Pyrimidinecarboxamide, N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-;N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide;SP-100030, 10 mM in DMSO
CAS号	154563-54-9
分子式	C14H5ClF9N3O
分子量	437.65
EINECS号
相关类别
Mol文件	154563-54-9.mol
结构式

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide 性质

熔点	166-167 °C
沸点	340.6±42.0 °C(Predicted)
密度	1.637±0.06 g/cm3(Predicted)
储存条件	Store at -20°C
溶解度	溶于二甲基亚砜
酸度系数(pKa)	8.97±0.70(Predicted)
形态	固体
颜色	米白色至浅黄色

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide 用途与合成方法

生物活性

SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat和其他T细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。

体外研究

SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC ₅₀ ≈30 nM).
ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030.

体内研究

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity.

Animal Model:	Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)
Dosage:	10 mg/kg
Administration:	I.p.; daily, starting at day 21 to the end of the study on day 34
Result:	Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.

安全信息

WGK Germany	WGK 3
存储类别	11 - 可燃固体

MSDS信息

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-110177	N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide SP-100030	154563-54-9	100 mg	4863元
2024/11/08	HY-110177	SP-100030		1 mg	560元

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide