2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate

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2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate Basic information
Product Name:2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate
Synonyms:2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate;PDdEC-NB;Carbonic acid, 2-methyl-2-(2-pyridinyldithio)propyl 4-nitrophenyl ester
CAS:1956318-90-3
MF:C16H16N2O5S2
MW:380.44
EINECS:
Product Categories:
Mol File:1956318-90-3.mol
2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate Structure
2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate Chemical Properties
Boiling point 531.9±50.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
pka1.73±0.19(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate Usage And Synthesis
UsesPDdEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).
IC 50Disulfide Cleavable Linker; Cleavable Linker
References[1] Flygare, John, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods.WO2016040825A120160317.
2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate Preparation Products And Raw materials
Tag:2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate(1956318-90-3) Related Product Information
4-Nitrophenyl 2-(pyridin-2-yldisulfanyl)propyl carbonate 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate 4-Nitrophenyl 4-(pyridin-2-yldisulfanyl)benzyl carbonate 4-Nitrophenyl 3-methylbutyl carbonate T -butyl-p-nitrophenyl carbonate Carbonic acid, ethyl 4-nitrophenyl ester