CP-544439

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CP-544439 manufacturers

  • CP-544439
  • CP-544439 pictures
  • $293.00
  • 2026-07-27
  • CAS:230954-09-3
  • Purity: 98.96%
  • Supply Ability: 10g
CP-544439 Basic information
Product Name:CP-544439
Synonyms:CP-544439;2H-Pyran-4-carboxamide, 4-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]tetrahydro-N-hydroxy-;UNII-516DO4KL5R;CP 544439,CP544439
CAS:230954-09-3
MF:C18H19FN2O6S
MW:410.42
EINECS:
Product Categories:
Mol File:230954-09-3.mol
CP-544439 Structure
CP-544439 Chemical Properties
Safety Information
MSDS Information
CP-544439 Usage And Synthesis
UsesCP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].
in vivo

In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1].

IC 50MMP-13: 0.75 nM (IC50); MMP-12: 0.24 nM (IC50); MMP-1: 420 nM (IC50); MMP-2: 1.6 nM (IC50); MMP-3: 16 nM (IC50); MMP-8: 1.4 nM (IC50); MMP-9: 12 nM (IC50); MMP-14: 7.4 nM (IC50)
References[1] Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profil DOI:10.1124/dmd.108.022566
[2] Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395. DOI:10.1016/j.bmcl.2004.04.083
CP-544439 Preparation Products And Raw materials
Tag:CP-544439(230954-09-3) Related Product Information
DC-Y13-27 ADAM8 Protein, MOUSE (HEK293, HIS) MMP-9 Protein, RAT (HEK293, HIS) Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]- MMP-2 Protein, HUMAN (HEK293, HIS) MMP-9 protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI)