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J & K SCIENTIFIC LTD.
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Product Name:1-[4-(Trifluoromethyl)-2-pyrimidinyl]-4-piperidinol , 97%
CAS:401930-07-2
Purity:97% Package:1G
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| | 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Basic information |
| Product Name: | 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL | | Synonyms: | 1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol 95+%;1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL;1-[4-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]-4-PIPERIDINOL;1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol 97%;1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol97%;4-Piperidinol, 1-[4-(trifluoromethyl)-2-pyrimidinyl]-;1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL ISO 9001：2015 REACH | | CAS: | 401930-07-2 | | MF: | C10H12F3N3O | | MW: | 247.22 | | EINECS: | | | Product Categories: | | | Mol File: | 401930-07-2.mol |  |
| | 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Chemical Properties |
| Melting point | 99 °C | | Boiling point | 366.4±52.0 °C(Predicted) | | density | 1.383 | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.51±0.20(Predicted) |
| Hazard Note | Harmful | | HS Code | 2933399990 |
| | 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Usage And Synthesis |
| Synthesis | Using 4-hydroxypiperidine (1.65 g, 16.3 mmol) and 2-chloro-4-trifluoromethylpyrimidine (2.98 g, 16.3 mmol) as the raw material, triethylamine (4.5 mL, 32.7 mmol) was added to isopropanol (60 mL) and the mixture was heated and refluxed for 5 hours. Upon completion of the reaction, it was cooled to room temperature and diluted with hexane and white precipitate formation was observed. The solids were removed by filtration and the filtrate was subsequently purified by passing it through a silica plug and washed sequentially with a 1:1 solvent mixture of EtOAc/hexane and pure EtOAc. The collected filtrate and washings were combined and concentrated to dryness to afford the target product 1-[4-(trifluoromethyl)-2-pyrimidinyl]-4-piperidinol (3.89 g). The exact mass calculated value of the product (C10H11F3N2O) was 247.09 and the measured LCMS value was 248.2 [M+H]+. | | References | [1] British Journal of Pharmacology, 2014, vol. 171, # 24, p. 5774 - 5789
[2] Patent: WO2014/74700, 2014, A1. Location in patent: Page/Page column 58 |
| | 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Preparation Products And Raw materials |
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