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| | 1,4-Dioxaspiro[4.5]decan-8-one Basic information |
| Product Name: | 1,4-Dioxaspiro[4.5]decan-8-one | | Synonyms: | cyclohexanedione monoethylene ketal;1,4-cyclohexanedione monoacetal;1 4-dioxiro[4.5]decan-8-one pharmaceutical intermediate;Substituted 1,2,4,9-tetrahydrospiro[carbazole-3,2'-[1,3]dioxane];1,4-Cyclohexanedione monoethlylene acetal;1,4-Cyclohexanedione monoethylene ketal for synthesis;4-Dioxaspiro[4.5]decan-8-one;Cyclohexane-1,4-dione monoethylene ketal | | CAS: | 4746-97-8 | | MF: | C8H12O3 | | MW: | 156.18 | | EINECS: | 610-352-2 | | Product Categories: | ketone;Dioxanes & Dioxolanes;Dioxolanes;Carbonyl Compounds;Heterocycles;blocks;BuildingBlocks;Liquid Crystal intermediates;bc0001 | | Mol File: | 4746-97-8.mol | ![1,4-Dioxaspiro[4.5]decan-8-one Structure](CAS/GIF/4746-97-8.gif) |
| | 1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties |
| Melting point | 70-73 °C (lit.) | | Boiling point | 112C | | density | 1.0887 (rough estimate) | | refractive index | 1.4430 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in chloroform & methanol. | | form | Crystalline Powder or Crystals | | color | White to beige | | Sensitive | Moisture Sensitive | | BRN | 117631 | | InChI | InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2 | | InChIKey | VKRKCBWIVLSRBJ-UHFFFAOYSA-N | | SMILES | O1C2(CCC(=O)CC2)OCC1 | | CAS DataBase Reference | 4746-97-8(CAS DataBase Reference) |
| | 1,4-Dioxaspiro[4.5]decan-8-one Usage And Synthesis |
| Chemical Properties | 1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals | | Uses | 1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex. | | Uses | 1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex. | | Uses | Intermediates of Liquid Crystals | | Application | 1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin. | | Purification Methods | Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.] |
| | 1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials |
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