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| | L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Basic information |
| | L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder |
| | L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White to off-white solid | | Uses | H-Arg-OtBu (dihydrochloride) is a membrane-targeting antimicrobial. H-Arg-OtBu (dihydrochloride) targets the negatively charged bacterial membrane via a combination of electrostatic and hydrophobic interactions. H-Arg-OtBu (dihydrochloride) can be used for bacterial infections diseases research[1]. | | in vivo | H-Arg-OtBu (dihydrochloride) (0.3% solutions treated for 3 times per day) has no signs of corneal inflammation and no evidence of an inflammatory response in rabbit corneal wound healing model[1].
H-Arg-OtBu (dihydrochloride) (0.3% solutions treated for 5 times per day) is effective in a mouse model of corneal infection by S. aureus and MRSA[1].
| | References | [1] Koh JJ, et al, Beuerman RW. Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. J Med Chem. 2015 Jan 22;58(2):739-52. DOI:10.1021/jm501285x |
| | L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Preparation Products And Raw materials |
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