396073-89-5
| 中文名称 | 396073-89-5 |
|---|---|
| 中文同义词 | 4-(二甲基氨基)-2-甲氧基-6-[[甲基[2-(4-硝基苯基)乙基]氨基]甲基]苯酚;化合物CDC25 PHOSPHATASE INHIBITOR I;化合物CDC25 PHOSPHATASE INHIBITOR I,10 MM DMSO 溶液;4-(二甲胺基)-2-甲氧基-6-((甲基(4-硝基苯乙基)氨基)甲基)苯酚 |
| 英文名称 | BN82002 HYDROCHLORIDE SALT |
| 英文同义词 | BN 82002;BN-82002;CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5 - Calbiochem;BN82002 hydrochloride;CDC25 Phosphatase Inhibitor I, BN82002;CDC25 Phosphatase Inhibitor I;Phenol, 4-(dimethylamino)-2-methoxy-6-[[methyl[2-(4-nitrophenyl)ethyl]amino]methyl]-;CDC25C,BN82002,CDC25A,BN-82002,inhibit,CDC25B3,MIA PaCa-2,Inhibitor,CDC25B2,BN 82002,Phosphatase;BN82002, 10 mM in DMSO |
| CAS号 | 396073-89-5 |
| 分子式 | C19H25N3O4 |
| 分子量 | 359.42 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 396073-89-5.mol |
| 结构式 |  |
396073-89-5 性质
| 熔点 | 92-93 °C |
|---|---|
| 沸点 | 532.6±50.0 °C(Predicted) |
| 密度 | 1.216±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：10 毫克/毫升 |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.07±0.48(Predicted) |
| 颜色 | 棕褐色 |
| InChI | 1S/C19H25N3O4/c1-20(2)17-11-15(19(23)18(12-17)26-4)13-21(3)10-9-14-5-7-16(8-6-14)22(24)25/h5-8,11-12,23H,9-10,13H2,1-4H3 |
| InChIKey | GOKYHQGRIIXMNE-UHFFFAOYSA-N |
| SMILES | [N+](=O)([O-])c1ccc(cc1)CCN(Cc2c(c(cc(c2)N(C)C)OC)O)C |
IC50: 2.4 μM (CDC25A), 3.9 μM (CDC25B2), 6.3 μM (CDC25B3), 5.4 μM (CDC25C), 4.6 μM (CDC25C-cat).
The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione, which has been reported to inhibit cell proliferation, is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC 50 of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC 50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-112776A | BN82002 hydrochloride | 396073-89-5 | 1 mg | 500元 |
| 2025/12/22 | HY-112776A | 396073-89-5 BN82002 hydrochloride | 396073-89-5 | 5 mg | 1100元 |