2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID

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Company Name: Accela ChemBio Inc.
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Products Intro: Product Name:2-[(2-Chloro-4-iodophenyl)amino]-3,4-difluorobenzoic Acid
CAS:303175-44-2
Purity:>97% Package:0.1g;0.25g;1g Remarks:SY473544
Company Name: career henan chemical co
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Products Intro: Product Name:2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID
CAS:303175-44-2
Purity:99% Package:1g;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:zapnometinib
CAS:303175-44-2
Purity:99.66% Package:5mg;40USD|10mg;60USD|25mg;73USD
Company Name: CR Corporation Limited
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Products Intro: Product Name:2-((2-Chloro-4-iodophenyl)amino)-3,4-difluorobenzoicacid
CAS:303175-44-2
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:zapnometinib；PD0184264;2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid;ATR-002;3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid
CAS:303175-44-2
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID manufacturers

  • zapnometinib
  • zapnometinib pictures
  • $40.00 / 5mg
  • 2026-03-13
  • CAS:303175-44-2
  • Min. Order:
  • Purity: 99.67%
  • Supply Ability: 10g
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Basic information
Product Name:2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID
Synonyms:3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid;2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID;Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-;ATR-002;PD0184264;2-(2-chloro-4-iodoanilino)-3;4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid;zapnometinib
CAS:303175-44-2
MF:C13H7ClF2INO2
MW:409.5544564
EINECS:
Product Categories:Amines;Aromatics;Chemical Amines
Mol File:Mol File
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Structure
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Chemical Properties
Melting point 230-231 °C
Boiling point 401.5±45.0 °C(Predicted)
density 1.946±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka3.25±0.36(Predicted)
color White to Brown
InChI1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20)
InChIKeyXCNBGWKQXRQKSA-UHFFFAOYSA-N
SMILESO=C(C1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Usage And Synthesis
Chemical PropertiesLight-Brown Solid
Uses2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoic Acid (cas# 303175-44-2) is a compound useful in organic synthesis.
Biological ActivityATR-002, a derivate of CI-1040, is a cell penetrant, potent and specific inhibitor of the Raf/MEK/ERK pathway. ATR-002 exhibits strong anti-influenza and anti-SARS-CoV-2 activity. It impairs the influenzas and SARS-CoV-2 viruses induced expression of pro-inflammatory cytokines.
in vivo

Zapnometinib (8.4-75 mg/kg/day; three times a day p.o.) reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].
Zapnometinib (150 mg/kg) exhibits AUC values of 860.02 and 1953.68 μg h/mL in mice by i.v. or oral route, respectively[1].

Animal Model:Female C57BL/6 mice (8 weeks; 21-24 g) were infected with H1N1pdm09[1]
Dosage:8.4, 25, 75 mg/kg/day (2.8, 8.4, 25 mg/kg)
Administration:P.o. three times a day
Result:Significantly reduced the virus titer at the dose of either 75 mg/kg/day or 25 mg/kg/day.
IC 50MEK: 5.7 nM (IC50)
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Preparation Products And Raw materials
Tag:2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID(303175-44-2) Related Product Information
3,4-Difluorobenzoic acid