| Company Name: |
Shanghai Universal Biotech Co.,Ltd
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| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:Gab1 Antibody
Package:100ul Remarks: 见优宁维官网
|
| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
|
| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:GAB1 antibody
Purity:99% Package:50ul/RMB 1280;100ul/RMB 2180
|
| Company Name: |
CUSABIO TECHNOLOGY LLC
|
| Tel: |
027-87196173 |
| Email: |
cusabio@163.com |
| Products Intro: |
Product Name:GAB1 Antibody
|
| Company Name: |
Hubei Serenity BioSolutions Co., Ltd.
|
| Tel: |
027-19371278702 18008634902 |
| Email: |
19384116026@163.com |
| Products Intro: |
Product Name:Mouse Monoclonal GAB1 Antibody
Package:20μl;50μl;100μl
|
| Company Name: |
GeneTex, Inc.
|
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:GAB1 antibody
|
|
| Product Name: | GAB1 antibody | | Synonyms: | GAB1 antibody;Mouse Monoclonal GAB1 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GAB1 antibody Structure]() |
| | GAB1 antibody Chemical Properties |
| | GAB1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | The Grb-associated binder family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold. Multiple tyrosine phosphorylation sites of Gab1 protein have been identified. Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase. Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ. Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2. | | References | [1] Holgado-Madruga, M. et al. (1996) Nature 379, 560-564.
[2] Weidner, K.M. et al. (1996) Nature 384, 173-176.
[3] Takahashi-Tezuka, M. et al. (1998) Mol. Cell. Biol. 18, 4109-4117.
[4] Ingham, R.J. et al. (2001) J Biol Chem 276, 12257-65.
[5] Lehr, S. et al. (1999) Biochemistry 38, 151-159.
[6] Rocchi, S. et al. (1998) Mol. Endocrinol. 12, 914-923.
[7] Yu, C.F. et al. (2001) J Biol Chem 276, 32552-8.
[8] Gual, P. et al. (2000) Oncogene 19, 1509-18.
[9] Cunnick, J.M. et al. (2001) J Biol Chem 276, 24380-7. |
| | GAB1 antibody Preparation Products And Raw materials |
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