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GeneTex, Inc. |
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NSJ Bioreagents |
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Abmart Inc |
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| | RACK1 antibody Chemical Properties |
| | RACK1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;D. melanogaster ;Zebrafish | | Background | The highly conserved receptor for activated C kinase 1, homologous to the β subunit of heterotrimeric G-proteins, was originally identified through its binding of active PKCβII and other classical PKC isoforms. RACK1 is a scaffold protein that recruits PKC and a wide range of other proteins to specific subcellular locations, promoting the formation of multiprotein complexes to induce and integrate various signaling pathways. One example of this is its enhancement of PKC-dependent JNK activation. RACK1 protein also resides in the eukaryotic ribosome, suggesting the possibility that RACK1 participates in the assembly of signaling complexes that regulate translation as well. RACK1 binds the SH2 domain of Src, and phosphorylation of RACK1 by Src occurs at Tyr228 after PKC activation. | | References | [1] Ron, D. et al. (1994) Proc Natl Acad Sci U S A 91, 839-43.
[2] López-Bergami, P. et al. (2005) Mol Cell 19, 309-20.
[3] McCahill, A. et al. (2002) Mol Pharmacol 62, 1261-73.
[4] Nilsson, J. et al. (2004) EMBO Rep 5, 1137-41.
[5] Chang, B.Y. et al. (2002) Oncogene 21, 7619-29. |
| | RACK1 antibody Preparation Products And Raw materials |
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