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| | Interphotoreceptor Retinoid Binding Protein Fragment IRBP Basic information |
| Product Name: | Interphotoreceptor Retinoid Binding Protein Fragment IRBP | | Synonyms: | Interphotoreceptor Retinoid Binding Protein Fragment IRBP;L-Aspartic acid, L-serylglycyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-isoleucyl-L-seryl-L-tyrosyl-L-leucyl-L-histidyl-L-prolylglycyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-histidyl-L-valyl- | | CAS: | 211426-18-5 | | MF: | C103H157N25O29 | | MW: | 2209.5 | | EINECS: | | | Product Categories: | | | Mol File: | 211426-18-5.mol |  |
| | Interphotoreceptor Retinoid Binding Protein Fragment IRBP Chemical Properties |
| Boiling point | 2290.5±65.0 °C(Predicted) | | density | 1.315±0.06 g/cm3(Predicted) | | Sequence | Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp |
| | Interphotoreceptor Retinoid Binding Protein Fragment IRBP Usage And Synthesis |
| Uses | Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)[1]. | | References | [1] Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87. DOI:10.4049/jimmunol.178.9.5578
[2] Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85. DOI:10.1189/jlb.0308189
[3] Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804. DOI:10.1167/iovs.13-13323 |
| | Interphotoreceptor Retinoid Binding Protein Fragment IRBP Preparation Products And Raw materials |
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