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| | Tubulysin E Basic information |
| Product Name: | Tubulysin E | | Synonyms: | Tubulysin E;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-α-methyl-, (αS,γR)- | | CAS: | 309935-58-8 | | MF: | C42H63N5O9S | | MW: | 814.05 | | EINECS: | | | Product Categories: | | | Mol File: | 309935-58-8.mol |  |
| | Tubulysin E Chemical Properties |
| Boiling point | 948.0±65.0 °C(Predicted) | | density | 1.178±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 4.51±0.23(Predicted) |
| | Tubulysin E Usage And Synthesis |
| Uses | Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2]. | | Definition | ChEBI: Tubulysin E is a butyrate ester. | | References | [1] Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. DOI:10.1002/anie.200906828
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041 |
| | Tubulysin E Preparation Products And Raw materials |
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