| Company Name: |
Guangzhou Younan Technology Co., Ltd
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| Tel: |
020-82000279 18988941452 |
| Email: |
YN_research@163.com |
| Products Intro: |
Product Name:KAG-308
CAS:1215192-68-9
Purity:0.98 Package:5mg;10mg;25mg;50mg;100mg
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:KAG-308
CAS:1215192-68-9
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:KAG-308
CAS:1215192-68-9
Package:100mg/RMB 186900;50mg/RMB 133000;25mg/RMB 94500
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| | KAG-308 Basic information |
| Product Name: | KAG-308 | | Synonyms: | KAG-308;2H-Cyclopenta[b]furan-5-ol, 3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxy-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(2H-tetrazol-5-yl)butylidene]-, (2Z,3aR,4R,5R,6aS)-;KAG 308,KAG308 | | CAS: | 1215192-68-9 | | MF: | C24H30F2N4O3 | | MW: | 460.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1215192-68-9.mol |  |
| | KAG-308 Chemical Properties |
| Boiling point | 615.6±65.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 5.00±0.10(Predicted) | | color | White to light yellow |
| | KAG-308 Usage And Synthesis |
| Uses | KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor[1]. | | References | [1] Watanabe Y, et al. KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. Eur J Pharmacol. 2015 May 5;754:179-89. DOI:10.1016/j.ejphar.2015.02.021 |
| | KAG-308 Preparation Products And Raw materials |
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