HS80 manufacturers
- HS80
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- $1980.00
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2026-04-21
- CAS:2138838-57-8
- Purity:
- Supply Ability: 10g
- HS80
-
- $1980.00
-
2025-08-23
- CAS:2138838-57-8
- Purity:
- Supply Ability: 10g
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| Product Name: | HS80 | | Synonyms: | HS80;HS-80,HS80;Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl]-;N-[(3S)-1-Benzylpyrrolidin-3-yl]-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine | | CAS: | 2138838-57-8 | | MF: | C19H22N4S | | MW: | 338.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2138838-57-8.mol |  |
| Boiling point | 519.0±50.0 °C(Predicted) | | density | 1.274±0.06 g/cm3(Predicted) | | pka | 8.67±0.40(Predicted) |
| Description | HS80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids. | | Uses | HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM. | | Definition | ChEBI: (S)-Fasnall is an N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine in which the chiral centre has S configuration. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer. It has a role as a fatty acid synthesis inhibitor and an EC 2.3.1.85 (fatty acid synthase) inhibitor. It is an enantiomer of a (R)-Fasnall. | | References | [1] Alwarawrah Y, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88. DOI:10.1016/j.chembiol.2016.04.011 |
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