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| | TINZAPARIN SODIUM Basic information |
| | TINZAPARIN SODIUM Chemical Properties |
| solubility | Dissolve 1.0 g in 10 mL of water R. The solution is clear (2.2.1) and not more intensely coloured than intensity 5 of the range of reference solutions of the most appropriate colour (2.2.2, Method II) |
| | TINZAPARIN SODIUM Usage And Synthesis |
| Uses | Innohep (Pharmion). | | Clinical Use |
Peri- and postoperative surgical thromboprophylaxis
Treatment of DVT and pulmonary embolism
Prevention of thrombus formation in extracorporeal circulation during HD | | Drug interactions | Potentially hazardous interactions with other drugs
Analgesics: increased risk of bleeding with NSAIDs
- avoid concomitant use with IV diclofenac;
increased risk of haemorrhage with ketorolac - avoid
concomitant use.
Nitrates: anticoagulant effect reduced by infusions of
glyceryl trinitrate.
Use with care in patients receiving oral
anticoagulants, platelet aggregation inhibitors, aspirin
or dextran. | | Metabolism | Low molecular weight heparins are partially metabolised by desulphation and depolymerisation. The kidneys are the major site of tinzaparin excretion (approximately 70
% based on animal studies). |
| | TINZAPARIN SODIUM Preparation Products And Raw materials |
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