E3 Ligase Ligand-Linker Conjugates 58 manufacturers
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| | E3 Ligase Ligand-Linker Conjugates 58 Basic information |
| Product Name: | E3 Ligase Ligand-Linker Conjugates 58 | | Synonyms: | E3 Ligase Ligand-Linker Conjugates 58;(S,R,S)-AHPC-PEG5-COOH;VH032-PEG5-COOH;VHL Ligand-Linker Conjugates 16;L-Prolinamide, N-(18-carboxy-1-oxo-4,7,10,13,16-pentaoxaoctadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;VH 032 amide-PEG5-acid;(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosan-1-oic acid;1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid | | CAS: | 2172820-14-1 | | MF: | C36H54N4O11S | | MW: | 750.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2172820-14-1.mol |  |
| | E3 Ligase Ligand-Linker Conjugates 58 Chemical Properties |
| storage temp. | -20°C, stored under nitrogen | | solubility | DMSO: ≥ 100 mg/mL (133.17 mM) | | form | Solid | | color | Colorless to off-white |
| | E3 Ligase Ligand-Linker Conjugates 58 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1]. | | Biological Activity | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1]. | | IC 50 | VHL | | storage | Store at -20°C | | References | [1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2. |
| | E3 Ligase Ligand-Linker Conjugates 58 Preparation Products And Raw materials |
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