CAY10762 manufacturers
- CAY10762
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- $1050.00
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2026-05-11
- CAS:2514-37-6
- Purity:
- Supply Ability: 10g
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| | CAY10762 Basic information |
| Product Name: | CAY10762 | | Synonyms: | CAY10762;1,2-Benzisothiazol-3(2H)-one, 2-(2-phenylethyl)-;2-(2-phenylethyl)-1,2-benzisothiazol-3(2H)-one;MAGL-IN-3 | | CAS: | 2514-37-6 | | MF: | C15H13NOS | | MW: | 255.33 | | EINECS: | | | Product Categories: | | | Mol File: | 2514-37-6.mol |  |
| | CAY10762 Chemical Properties |
| Melting point | 92.5-93.5 °C | | Boiling point | 430.4±38.0 °C(Predicted) | | density | 1.252±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | -2.19±0.20(Predicted) |
| | CAY10762 Usage And Synthesis |
| Uses | CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50=34.1 nM). It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. | | Biological Activity | CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 34.1 nM).1 It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. | | References | 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(3)1261-1280(2020) |
| | CAY10762 Preparation Products And Raw materials |
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