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| | CATHEPSIN K SUBSTRATE Basic information |
| Product Name: | CATHEPSIN K SUBSTRATE | | Synonyms: | CATHEPSIN K SUBSTRATE;Abz-HPGGPQ-EDDnp;L-Glutamamide, N-(2-aminobenzoyl)-L-histidyl-L-prolylglycylglycyl-L-prolyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]- | | CAS: | 221055-89-6 | | MF: | C40H50N14O12 | | MW: | 918.91 | | EINECS: | | | Product Categories: | | | Mol File: | 221055-89-6.mol |  |
| | CATHEPSIN K SUBSTRATE Chemical Properties |
| Boiling point | 1483.569±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.468±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 12.879±0.46(predicted) | | Sequence | {Abz}-His-Pro-Gly-Gly-Pro-Gln-{EDDnp} |
| | CATHEPSIN K SUBSTRATE Usage And Synthesis |
| Uses | Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.) |
| | CATHEPSIN K SUBSTRATE Preparation Products And Raw materials |
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