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| | 4-Bromopyridine-2-carboxylic acid Basic information |
| | 4-Bromopyridine-2-carboxylic acid Chemical Properties |
| Melting point | 172-174 | | Boiling point | 347.8±27.0 °C(Predicted) | | density | 1.813±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Sparingly Soluble in DMSO, Methanol, Water | | form | Solid | | pka | 3.25±0.10(Predicted) | | color | Off-White | | Water Solubility | Sparingly soluble in dimethyl sulfoxide , methanol and water. | | InChI | InChI=1S/C6H4BrNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10) | | InChIKey | RPHHYRNGCJYQSP-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)=NC=CC(Br)=C1 | | CAS DataBase Reference | 30766-03-1(CAS DataBase Reference) |
| | 4-Bromopyridine-2-carboxylic acid Usage And Synthesis |
| Chemical Properties | 4-Bromopyridine-2-carboxylic acid is fine needles | | Uses | 4-Bromopyridine-2-carboxylic acid is a useful synthetic intermediate | | Uses | 4-Bromopicolinic acid is a useful synthetic intermediate. Also used as a intermediate for agrochemical, pharmaceutical and dyestuff field. | | Synthesis | 4.1.12 Synthesis of 5-bromopyridine-2-carboxylic acid (16): In a 250 mL three-necked flask equipped with a stirrer, thermometer, and condenser tube, 100 mL of water and 4-bromo-2-methylpyridine (15) (4.0 g, 23 mmol) were added. After the mixture was stirred and heated to 80 °C, potassium permanganate (KMnO4) (16.6 g, 105 mmol) was added in three batches at 1 h intervals. The reaction mixture was kept stirred at 80 °C for 3-4 hours. After completion of the reaction, the clarified filtrate was obtained by filtration. The pH of the filtrate was adjusted to 4-5 with concentrated hydrochloric acid (HCl), at which time a small amount of white solid was precipitated, which was a small amount of product (16). After filtration, the filtrate was concentrated in vacuum. To the concentrated residue, an appropriate amount of ethanol was added to dissolve the compound (16), at which time a large amount of white solid precipitated, which was removed by filtration. Finally, the filtrate was concentrated in vacuum to give a light yellow solid product (16) (1.70 g, 33% yield). | | References | [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3228 - 3236
[2] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 292-293
[3] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 204
[4] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 292-293
[5] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 292-293 |
| | 4-Bromopyridine-2-carboxylic acid Preparation Products And Raw materials |
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