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Shanghai Chaolan Chemical Technology Center
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Sales@ATKchemical.com |
| Products Intro: |
Product Name:H-Gly-Arg-PNA.2HCl
CAS:125455-61-0
Purity:98 Package:1G,5G,10G,50G,100G,500G
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GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE manufacturers
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| | GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE Basic information |
| | GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE Chemical Properties |
| storage temp. | −20°C | | solubility | DMF: 20mg/mL; DMSO: 3mg/mL; PBS (pH 7.2): 3mg/mL | | form | A solid | | InChIKey | UMNMBKCWESYUMR-LCJJWKFENA-N | | SMILES | C1(C=CC([N+]([O-])=O)=CC=1)NC(=O)[C@@H](NC(=O)CN)CCCNC(=N)N.Cl.Cl |&1:12,r| |
| | GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE Usage And Synthesis |
| Description | H-Gly-Arg-pNA is a colorimetric substrate for thrombin. Thrombin preferentially binds to and cleaves the Gly-Arg (GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity. | | Uses | H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity[1]. | | References | [1] Hortin G L, et al. Macromolecular chromogenic substrates for measuring proteinase activity[J]. Clinical chemistry, 2001, 47(2): 215-222. PMID:11159769 |
| | GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE Preparation Products And Raw materials |
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