2-[(2-Chlorobenzyl)sulfanyl]-4-hydroxy-6-phenyl-5-pyrimidinecarbonitrile manufacturers
- BET-IN-7
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- $1520.00
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2026-04-20
- CAS:303985-05-9
- Purity:
- Supply Ability: 10g
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| | 2-[(2-Chlorobenzyl)sulfanyl]-4-hydroxy-6-phenyl-5-pyrimidinecarbonitrile Basic information |
| | 2-[(2-Chlorobenzyl)sulfanyl]-4-hydroxy-6-phenyl-5-pyrimidinecarbonitrile Chemical Properties |
| Boiling point | 512.9±60.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | pka | 4.66±0.50(Predicted) |
| | 2-[(2-Chlorobenzyl)sulfanyl]-4-hydroxy-6-phenyl-5-pyrimidinecarbonitrile Usage And Synthesis |
| Uses | BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1]. | | References | [1] Chen X, et al. Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238: DOI:10.1016/j.ejmech.2022.114423 |
| | 2-[(2-Chlorobenzyl)sulfanyl]-4-hydroxy-6-phenyl-5-pyrimidinecarbonitrile Preparation Products And Raw materials |
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