1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE manufacturers
- Bromo-PEG4-bromide
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- $0.00 / 100mg
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2025-07-19
- CAS:57602-02-5
- Min. Order:
- Purity:
- Supply Ability: 10g
- Br-PEG4-Br
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- $0.00 / 5g
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2025-06-07
- CAS:57602-02-5
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE Basic information |
| Product Name: | 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE | | Synonyms: | 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE;1,2-Bis[2-(2-bromoethoxy)ethoxy]ethane;1,14-Dibro-3,6,9,12-tetraoxatetradecane;Br-PEG4-bromide;Br-PEG4-CH2CH2Br;CAS_57602-02-5;Br-PEG4-br,Bromo-PEG4-bromide;3,6,9,12-Tetraoxatetradecane, 1,14-dibromo- | | CAS: | 57602-02-5 | | MF: | C10H20Br2O4 | | MW: | 364.07 | | EINECS: | | | Product Categories: | Nitric Oxide Reagents;Polyethyleneglycol Derivative;Cross Linking Reagents | | Mol File: | 57602-02-5.mol |  |
| | 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform | | form | Clear Light Yellow Liquid | | color | Colorless to light yellow |
| | 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE Usage And Synthesis |
| Description | Bromo-PEG4-bromide is a PEG linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | | Chemical Properties | Clear Light Yellow Liquid | | Uses | A cross-linking reagent. | | Synthesis | The general procedure for the synthesis of dibromopenta PEG from pentaethylene glycol disulfonate (CAS: 109789-39-1) is as follows: in Example 2, pentaethylene glycol disulfonate (3.94 g, 10 mmol) was dissolved with tetrabutylammonium bromide (13.3 g) in acetonitrile (50 mL). The reaction mixture was stirred for 16 h under the protection of nitrogen atmosphere. Upon completion of the reaction, the solvent was removed by distillation. Subsequently, liquid-liquid extraction was performed by adding ethyl acetate and water to the residue. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. Finally, the target product dibromopenta PEG (2.73 g, 75% yield) was purified by column chromatography. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 3.49 (t, 4H), 3.69 (s, 12H), 3.84 (t, 4H). | | IC 50 | PEGs | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 557 - 560
[2] Steroids, 2006, vol. 71, # 10, p. 911 - 921
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 636 - 643
[4] Patent: US2016/82117, 2016, A1. Location in patent: Paragraph 0046 |
| | 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE Preparation Products And Raw materials |
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