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Alfa Aesar |
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400-6106006 |
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saleschina@alfa-asia.com |
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Ark Pharm, Inc. |
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847-367-3680 |
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sales@arkpharminc.com |
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Energy Chemical |
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| | 3,5-Bis(trifluoromethyl)anisole Basic information |
| Product Name: | 3,5-Bis(trifluoromethyl)anisole | | Synonyms: | 1-Methoxy-3,5-bis(trifluoromethyl)benzene;1,3-Bis(trifluoromethyl)-5-methoxybenzene, 3,5-Bis(trifluoromethyl)phenyl methyl ether;3,5-Bis-trifluormethyl-aniso;Benzene, 1-methoxy-3,5-bis(trifluoromethyl)-;3,5-Bis(trifluoromethyl)anisole | | CAS: | 349-60-0 | | MF: | C9H6F6O | | MW: | 244.13 | | EINECS: | 670-792-6 | | Product Categories: | | | Mol File: | 349-60-0.mol |  |
| | 3,5-Bis(trifluoromethyl)anisole Chemical Properties |
| Boiling point | 158-160°C | | density | 1.352 | | refractive index | 1.4075 | | Fp | 158-160°C | | storage temp. | 2-8°C | | Appearance | Colorless to light yellow Liquid | | BRN | 2533238 | | CAS DataBase Reference | 349-60-0(CAS DataBase Reference) |
| Hazard Codes | F | | Risk Statements | 10 | | Safety Statements | 16 | | RIDADR | 3271 | | Hazard Note | Flammable | | HazardClass | 3 | | PackingGroup | III | | HS Code | 2909309090 |
| Provider | Language |
|
ALFA
| English |
| | 3,5-Bis(trifluoromethyl)anisole Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3,5-bis(trifluoromethyl)anisole from 3,5-bis(trifluoromethyl)bromobenzene and sodium methanol was as follows: 25 g of 1-bromo-3,5-bis(trifluoromethyl)benzene (85 mmol) was mixed with 366 mg of copper(I) bromide (CuBr, 3 mol%), 1.57 g of 18-crown-6 (7 mol%), and 92.3 g of sodium methanol in methanol ( 30% concentration, 21% precursor concentration) were mixed and heated to 105 °C. The reaction conversion was >97% as determined by GC (total reaction time 22 h). Subsequently, the reaction mixture was poured into 175 g of water and the pH was adjusted to 5-6 by dropwise addition of hydrochloric acid and then filtered through diatomaceous earth. The aqueous phase was extracted twice with 150 g of dichloromethane. The organic phases were combined and purified by vacuum fractional distillation to afford 16.5 g of 3,5-bis(trifluoromethyl)anisole (68 mmol, 79.4% yield) with a GC purity of >98.5%. | | References | [1] Patent: US2008/71084, 2008, A1. Location in patent: Page/Page column 4 |
| | 3,5-Bis(trifluoromethyl)anisole Preparation Products And Raw materials |
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