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| | BOC-TRANS-4-AMINOCYCLOHEXANOL Basic information |
| | BOC-TRANS-4-AMINOCYCLOHEXANOL Chemical Properties |
| Melting point | 172-173°C | | Boiling point | 337.7±31.0 °C(Predicted) | | density | 1.06±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform. Ethyl Acetate | | pka | 12.36±0.40(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChIKey | DQARDWKWPIRJEH-KYZUINATSA-N | | CAS DataBase Reference | 111300-06-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | Hazard Note | Irritant | | HS Code | 2906190090 |
| | BOC-TRANS-4-AMINOCYCLOHEXANOL Usage And Synthesis |
| Uses | trans-4-(Boc-amino)cyclohexanol is an intermediate in the synthesis of potent activators of Heme-regulated inhibitor kinase. | | Synthesis | Step 1: trans-4-Aminocyclohexanol hydrochloride (5.0 g, 33 mmol) was dissolved in 1,4-dioxane (100 mL) and the resulting solution was cooled to 0 °C. Aqueous sodium hydroxide solution (40 mL, 1 N) was slowly added and the reaction mixture was stirred for 15 minutes. Subsequently, di-tert-butyl dicarbonate (7.9 g, 36 mmol) pre-dissolved in 1,4-dioxane (65 mL) was added. The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the reaction mixture was neutralized with 1 N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed sequentially with 1 N hydrochloric acid, water and saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give the white solid product trans-4-BOC-aminocyclohexanol (7.0 g, 100% yield). Mass spectrometry analysis showed (M + H)+ = 216.15. | | References | [1] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 47
[2] Heterocycles, 2002, vol. 58, p. 471 - 504
[3] Patent: WO2007/67629, 2007, A1. Location in patent: Page/Page column 63 |
| | BOC-TRANS-4-AMINOCYCLOHEXANOL Preparation Products And Raw materials |
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