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| | 2-(Trifluoromethyl)benzoic acid Basic information | | Uses |
| | 2-(Trifluoromethyl)benzoic acid Chemical Properties |
| Hazard Codes | Xn,N,Xi | | Risk Statements | 20/22-51/53-36/37/38 | | Safety Statements | 61-36-26 | | RIDADR | UN 1549 6.1/PG 3 | | WGK Germany | 2 | | F | 1-10 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29163990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-(Trifluoromethyl)benzoic acid Usage And Synthesis |
| Uses | 2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B. | | Chemical Properties | slightly yellow to yellow-brown crystalline powder | | Uses | 2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B. | | Uses | 2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1HNMR spectroscopy. | | Definition | ChEBI: A benzoic acid carrying a trifluoromethyl substituent at the 2-position. | | Synthesis | In a 5L stainless steel high-pressure reactor equipped with a mixer and a thermometer, the temperature was lowered to below 5C, hydrogen fluoride and 2-trichloromethyl dichlorobenzyl were added sequentially and the mass ratio of the two was 0.2:1, and then the catalyst perfluorooctane sulfonyl fluoride was added, and the mass ratio of 2-trichloromethyl dichlorobenzyl to the catalyst was 1:0.001, and the reaction pressure was controlled to be 2.5-2.8MPa for 4 hours. The temperature was raised to 80-90C, and the reaction pressure was controlled at 2.5-2.8 MPa for 4 hours. Sampling, GC detection, the intermediate product 2-difluoromonochloromethyl dichlorobenzyl content of 0.3%. At the end of the reaction, the excess hydrogen fluoride was removed by nitrogen purging, and neutralized with aqueous potassium carbonate to pH=6-7. After standing, the product 2-trifluoromethyl dichlorobenzyl chloride was isolated with 96.6% content and 94.1% yield.
The fluorination reaction product 2-trifluoromethyl dichlorobenzyl and nitric acid were reacted to obtain the target compound 2-trifluoromethyl benzoic acid after acid hydrolysis and oxidation reaction.
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| | 2-(Trifluoromethyl)benzoic acid Preparation Products And Raw materials |
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