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| | IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Basic information |
| | IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Chemical Properties |
| Melting point | 48-51 °C (lit.) | | Boiling point | 83-87 °C(Press: 0.6 Torr) | | density | 1.35±0.1 g/cm3(Predicted) | | Fp | 230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 2.41±0.10(Predicted) | | form | Solid | | color | Pale Yellow | | InChI | InChI=1S/C5H9N3O2S/c1-7(2)11(9,10)8-4-3-6-5-8/h3-5H,1-2H3 | | InChIKey | YRRWNBMOJMMXQY-UHFFFAOYSA-N | | SMILES | C1N(S(N(C)C)(=O)=O)C=CN=1 | | CAS DataBase Reference | 78162-58-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HS Code | 2933299090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Usage And Synthesis |
| Chemical Properties | IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is Yellow Semi-Solid | | Uses | IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 r eceptor. | | Uses | 1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor. | | Uses | 1-(Dimethylsulfamoyl)imidazole may be used to synthesize 1-(dimethylsulfamoyl)-2-imidazolecarboxaldehyde. | | General Description | 1-(Dimethylsulfamoyl)imidazole is an imidazole derivative. | | Synthesis | The general procedure for the synthesis of N,N-dimethylimidazole-1-sulfonamide from imidazole and N,N-dimethylaminosulfonyl chloride is as follows: with reference to Example 7-1 N,N-dimethyl-1H-imidazole-1-sulfonamide, imidazole (5.00 g, 73.6 mmol) was dissolved in toluene (80 ml), followed by the addition of triethylamine (9.52 ml, 68.4 mmol) and N,N-dimethylaminosulfonyl chloride (6.77 ml, 63.3 mmol). The reaction mixture was stirred at room temperature for 8 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to azeotropic distillation with hexane to give the final N,N-dimethylimidazole-1-sulfonamide (10.9 g, 98% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz) with δ-values of 7.87 (s, 1H), 7.23 (d, 1H, J = 1.4 Hz), 7.11 (d, 1H, J = 1.4 Hz), 2.82 (s, 6H). | | References | [1] Patent: EP1647546, 2006, A1. Location in patent: Page/Page column 30
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984, # 3, p. 481 - 486
[3] Organic Letters, 2005, vol. 7, # 5, p. 929 - 931
[4] Tetrahedron, 2007, vol. 63, # 4, p. 947 - 952
[5] Journal of the Iranian Chemical Society, 2012, vol. 9, # 6, p. 951 - 955 |
| | IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Preparation Products And Raw materials |
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